Pyrroloquine Quinone, zoro aka na PQQ, bụ otu ihe ọmụmụ ọhụụ nwere vitamin. A na-ahụta ya n'ọtụtụ ebe, osisi na anụmanụ, dị ka soybo soybe ma ọ bụ na Nasto, ose, papaya, ara, mmiri ara, mmiri ara ehi, wdg ara.
N'afọ ndị na-adịbeghị anya, PQQ aghọọla otu n'ime "kpakpando" ndị na-adọrọ adọrọ mmasị. Na 2022 na 2023, obodo m kwadoro PQQ nwapụtara site na njikọta na gbaa ụka dị ka nri.
Ọrụ ndu nke PQQ bụ ihe na-eme ka ihe abụọ mee ihe. Nke mbu, o nwere ike ikwado uto na mmepe nke mitochondria ma na-akpali uto nke sel mmadu; Nke abụọ, ọ nwere ezigbo antioxidant Njirimara, nke nwere ike inyere wepu radicals na belata mmebi cel. Ọrụ abụọ a na-eme ka ọ rụọ ọrụ dị ike na ahụike ụbụrụ, ahụike obi, ahụike metabolic na akụkụ ndị ọzọ. N'ihi na ahụ mmadụ enweghị ike ịhazi PQQ n'onwe ya, ọ dị mkpa ka etinyere ya site na mgbakwunye nri.
Na February 2023, ndị nchọpụta Japan na-ebipụta akwụkwọ nyocha nke Qunone na ndị okenye "na magazin" na ndị na-eto eto na ndị okenye na Japan. Nsonaazụ nyocha dị mma.
Ọmụmụ ihe a bụ ebe a na-ahụ maka nwa nwoke na-achịkwa nke gụnyere ụmụ nwoke ndị Japan dị afọ iri abụọ na isii, nke nwere obere ọgụgụ isi na-amachibido iwu mbụ ha n'oge ọmụmụ ihe. Ìgwè mmadụ. E kewapụrụ isiokwu nyocha na otu aka na otu aka na otu njikwa placebo, ma na-achịkwa pqq (20 mg / d) ma ọ bụ placebo capsules kwa ụbọchị maka izu iri na abụọ. Ejiri usoro nnwale ntanetị nke ụlọ ọrụ maka njirimara na izu 0/8/12. Nnwale nghọta na-enyocha ọrụ ụbụrụ 15 na-esote.
Nsonaazụ ahụ gosiri na e jiri ya tụnyere otu njikwa placebo, mgbe izu 12 nke PQQ Mgbe izu PQQ nke PQQ nwere, na-eto eto na-eto eto na-eto eto, nhazi ọsọ na akara akara na-eme ka ọ mụbaa.
Na Machị 2023, akwụkwọ akụkọ a ma ama na-ebipụta akwụkwọ na-ebipụta akwụkwọ nyocha nke Qunonone Quinone na-eme ka ọrụ Brain na-eme ka ọrụ Brain na ndị okenye ". Ọmụmụ ihe a na-enyocha mmetụta PQQ na ọrụ ọgụgụ isi nke ndị okenye dị afọ 20-65, na-agbasawanye ọmụmụ nke PQQ site n'aka ndị na-eto eto. Ọmụmụ ihe ahụ gosipụtara na PQQ nwere ike ime ka ọrụ ọgụgụ isi nke ndị nọ n'afọ ndụ niile.
Nchọpụta ahụ achọtala na PQQ, nwere ike imelite ọrụ ụbụrụ n'oge ọ bụla, ma na-atụ anya na ojiji nke PQQ dị ka nri na-arụ ọrụ na ndị agadi.
Na Mee 2023, Ọnwụ Ọnwụ bipụtara mpempe akwụkwọ nyocha na-egbochi ndị Mitoplagy na nkwagharị Mitochondrial nke Mesanymeral Steam. Ọmụmụ ihe a achọtara na-enyocha ma na-enyocha ma ọ bụrụ na onye na - ebute ihe na - enweghị ike (MSCS) na - enwe nsogbu. Mgbanwe na-eweghachi ahụike Mitochondrial iji belata mitiophagy.
Ọmụmụ ihe a na-enye nghọta mbụ nke mitiophary nke mitiophal nke na-enweghị nsogbu ma gosipụta na enwere ike weghachi ya na ahụike Mtochunceria site na PQQ Iwu iji belata mitiophagry ahụ ike.
Na Mee 2023, a bipụtara akụkọ nyocha nke "Pyrroloquinoline-Qunone iji belata abụba nke oke" na-achịkọta ọmụmụ ihe, nke chịkọtara ọmụmụ anụmanụ na ọmụmụ ihe abụọ.
Nsonaazụ gosipụtara na PQQ nwere ike belata abụba anụ ahụ, ọkachasị abụba na abụba nke vicer, si na-egbochi oke ibu. Site na nyocha nke ụkpụrụ, PQQ tumadi na-egbochi Lipgenesis ma belata mkpokọta abụba site na imezi ọrụ ma ọ bụ ịkwalite lipid metabolism.
Na Septemba 2023, sel sel na-ebipụta akwụkwọ nyocha aha ya na-eme ka ihe omume na-agba ọsọ na-eme ihe na-agagharị site na mmeghachi omume nke MCN2. Ọmụmụ ihe a, site na nnwale na ụmụ oke, achọpụtara na ihe mgbakwunye PQQ nwere ike igbochi osteoposesis na-aka nká. Usoro ihe eji eme ihe ike nke ike PQQ nwere ike na-enye nnwale nnwale maka iji PQQ dị ka mgbakwunye nri maka igbochi osteoporosis.
Ọmụmụ ihe a na-ekpughe ọrụ dị irè na usoro ọhụụ nke PQQ na-egbochi ma na-emeso PQQ nwere ike iji ya dị ka mgbakwunye nri ma na-eme ka ovesteoposis dị mma. N'otu oge ahụ, ekpughere ya na PQQ na-arụ ọrụ MCM3-NRF2 Mpempe akwụkwọ ndụ mkpụrụ ndụ Asteaxidants, na-eme ka usoro ọkpụkpọ Osteoblast Osteocalast, na-emekwa ka ọ bụrụ usoro ọkpụkpụ osteoblast. Ọrụ n'ime ọrụ nke mmekọahụ osteoporosis.
Na Septemba 2023, akwụkwọ akụkọ acapatathol Kọmunist na-ebipụta akwụkwọ site na ndị ọkachamara na ụlọ ọgwụ Ophtholka, Sweden, na Ngalaba bayoloji nke Mahadum nke Pisalytali. A na-akpọ ya "pyrroloquononine Qunone na-awụpụ na vitro na vivo ma na-enye ndị Ganglaion Ganglion Ganglion Ganglion Ganglion Ganglion Cell Nudoplotoction." Nchọpụta egosila na PQQ nwere mmetụta nchebe na mkpụrụ ndụ Ganglion (RGC) ma nwee nnukwu ikike na -echegharị ọhụụ na-emegide apostosis.
Nchọpụta ahụ na-akwado ọrụ PQQ dị ka akwụkwọ ọgụgụ seuroptotional na-ahụ maka mkpụrụ ndụ nke sel na-azụ ahịa mgbe ị na-ebelata ihe ize ndụ nke mmetụta ndị ọzọ. N'otu oge ahụ, ndị ọrụ nyocha kwenyere na inyefe PQQ bụ nhọrọ dị irè maka ịnọgide na-enwe ahụ ike.
Na December 2023, ndị otu nnyocha si na ụlọ ọgwụ nke Shanghai nke ụlọ akwụkwọ Mahadum Tyrrononoline na-egosi na ị ga-eme ka ọ bụrụ nke na-ahụ maka ihe ngosi nke PQQ nwere ike ịhazi flora nke eriri afọ A na-ahụta mmebi eriri afọ, ma melite ọrụ thyroid.
Ọmụmụ ihe ahụ hụrụ nsonaazụ PQQ na GD ụmụ oke na flora na-eme eriri afọ:
01 Mgbe PQQ gbaghaara, a na-ebe a na-egbu egbu na T4 ụmụ oke na-ebelata, na nha nke thyroid gland na-ebelata.
02 pqq na-ebelata mbufụt na nrụgide oxiditive, ma belata obere eriri afọ.
03 PQQ nwere mmetụta dị ukwuu na iweghachi ọdịiche dị iche iche na ihe mejupụtara microbiatio.
04 ma e jiri ya tụnyere GD GD, ọgwụgwọ PQQ nwere ike belata ọtụtụ Lactobacilli na ụmụ oke (nke a bụ ihe ị ga-enwe maka ọgwụgwọ maka usoro GD).
Na nchịkọta, mgbakwunye PQQ nwere ike ịhazi ọrụ thyroid rụọ ọrụ, belata mmebi nke thyroid, ma belata mbufụt na nrụgide oxiditive, si na-edozi obere mmebi eriri afọ. Na PQQ nwekwara ike iweghachi ọdịiche nke eriri afọ.
Na mgbakwunye na ọmụmụ ndị dị n'elu na-egosi ọrụ dị elu na ike na-akparaghị ókè iji melite ahụike mmadụ, ọmụmụ gara aga emeela ka ọrụ siri ike nke PQQ.
Na Ọktọba 2022, akwụkwọ nyocha akpọrọ "Pyrrololoquinoline Quinone (PQQ) na-eme ka ọ na-enye ọgbụgba nkà ma ọ bụ na-enye ya ohere iji nweta ọrụ PQQ na imezi ọbara mgbali elu.
Nsonaazụ na-egosi na PQQ nwere ike belata matiochondrialial nke na-enweghị atụ na akwara pulnomary dị mma ma na-egbu oge ọganihu nke oke na oke oke. Enwere ike iji PQQ mee ihe dị ka onye ọrụ nwere ike ịhaziwanye ọbara mgbali elu.
Na Jenụwarị 2020, mpempe akwụkwọ nyocha akpọrọ Pryroloquine Quinone na-egbu onye bipụtara na plọn na-egosi na PQQ na mkpụrụ ndụ mmadụ. , nsonaazụ gosipụtara na PQQ egbu egbuwo sel na-akawanye njọ mmadụ ma nwee ike ịgbasa.
Ndị na-eme nchọpụta chọpụtara na PQQ nwere ike igbu oge na-egbu mmadụ, ma kọwakwuo nkwubi okwu a site na ngosipụta nke ọtụtụ ndumarki dị ka P21, P16, na Jagged1. A na-atụ aro na pqq nwere ike ime ka ahụike dị elu karịa nke ndị mmadụ na-agbatịkwu afọ.
Na Mach 2022, e bipụtara akwụkwọ nyocha akpọrọ Alkylatin na-egbochi onye na-eme ka ọ bụrụ na ndị na-eme ka ọ dị na ụmụ oke, na-achọ ịmụpụta ma PQQ nri na-echebe megide onye na-akwado Alkyliting na-akwado ya. mmetụta.
Nsonaazụ gosiri na PQQ mgbaze na-abawanye ibu na nha nke ovaries, weghachiri ihe ndị mebiri emebi na Mice na-emeso ndị ọrụ alkylatik. Ọzọkwa, PQQ mgbaze na-eme ka afọ ime dị ime na nha na-awụpụta ya na nchịkọta Alkyliting na-agwọ anụ ahụ. Nsonaazụ ndị a na-akọwapụta ihe enyemaka nke PQQ gbaghaara na Alkyliting na-enye onye na-akwado Obsian Dysfunction.
Mmechi
N'ezie, dị ka mgbakwunye nri ọhụrụ, a matara maka nsonaazụ ya dị mma na nri nri na ahụ ike. N'ihi ọrụ ya dị ike, nchekwa dị elu na nkwụsi ike dị ukwuu, ọ nwere atụmanya mmepe nke nri na-arụ ọrụ.
N'afọ ndị na-adịbeghị anya, nke nwere ihe ọmụma, PQQ enwetala asambodo arụmọrụ zuru oke ma na-ejikwa nri ma ọ bụ nri dị na United States, Europe na obodo ndị ọzọ na mpaghara. Dị ka ndị na-azụ ahịa n'ụlọ na-aga n'ihu na-eme ka ihe dị omimi, a kwenyere na PQQ, dị ka ihe oriri ọhụrụ, ga-eke ụwa ọhụrụ n'ahịa ụlọ.
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