Na-ewebata PQQ: Ihe nkwalite ike kacha elu maka uche na ahụ

Na-ewebata PQQ: Ihe nkwalite ike kacha elu maka uche na ahụ

Pyrroloquinoline quinone, nke a na-akpọ PQQ, bụ otu ọhụrụ prosthetic nwere ọrụ physiological yiri ya na vitamin. A na-achọta ya na prokaryotes, osisi na anụ mammals, dị ka soybean fermented ma ọ bụ natto, akwụkwọ ndụ akwụkwọ ndụ akwụkwọ ndụ, mkpụrụ kiwi, pasili, tii, pọọpọ, akwụkwọ nri, celery, mmiri ara ara, wdg.

N'afọ ndị na-adịbeghị anya, PQQ abụrụla otu n'ime nri "kpakpando" nke dọtara uche zuru oke. Na 2022 na 2023, obodo m kwadoro PQQ mepụtara site na njikọ na gbaa ụka dị ka akụrụngwa nri ọhụrụ.

Ọrụ ndu nke PQQ na-etinyekarị uche na akụkụ abụọ. Nke mbụ, ọ nwere ike ịkwado uto na mmepe nke mitochondria ma kpalie uto ngwa ngwa nke mkpụrụ ndụ mmadụ; nke abụọ, ọ nwere ezigbo antioxidant Njirimara, nke nwere ike inye aka wepụ free radicals na ibelata cell mmebi. Ọrụ abụọ a na-eme ka ọ rụọ ọrụ dị ike na ahụike ụbụrụ, ahụike obi, ahụike metabolic na akụkụ ndị ọzọ. N'ihi na ahụ mmadụ enweghị ike ịmepụta PQQ n'onwe ya, ọ dị mkpa ka agbakwunye ya site na nri nri.

01.PQQ na-arụ n'ịkwalite cognition ka a na-eji kpọrọ ihe

Na February 2023, ndị nchọpụta Japan bipụtara akwụkwọ nyocha nke akpọrọ "Pyrroloquinoline quinone disodium nnu na-eme ka ọrụ ụbụrụ dịkwuo mma ma ndị na-eto eto na ndị okenye" ​​na magazin "Food & Function", na-ewebata ihe ọmụma nke PQQ na ndị na-eto eto na ndị agadi na Japan. Nsonaazụ nyocha emelitere.

Ọmụmụ ihe a bụ nyocha nke a na-achịkwa nke placebo okpukpu abụọ nke gụnyere 62 ndị ikom Japan dị mma dị afọ 20-65, na Mini-Mental State Scale scores ≥ 24, bụ ndị nọgidere na-ebi ndụ mbụ ha n'oge oge ọmụmụ. Ìgwè nwanyị. E kewara ihe nyocha n'enweghị usoro ka ọ bụrụ otu ntinye aka na otu nchịkwa placebo, a na-ejikwa ọnụ PQQ (20 mg/d) ma ọ bụ capsules placebo kwa ụbọchị maka izu iri na abụọ. Ejiri usoro nyocha ịntanetị nke ụlọ ọrụ mepụtara maka njirimara na izu 0/8/12. Nnwale ọgụgụ isi na-enyocha ọrụ ụbụrụ iri na ise ndị a.

Nsonaazụ gosiri na ma e jiri ya tụnyere ndị na-achịkwa placebo, mgbe izu iri na abụọ nke oriri PQQ gasịrị, ebe nchekwa ihe mgbagwoju anya na ọnụ ọgụgụ okwu ọnụ nke ìgwè niile na ndị agadi mụbara; mgbe izu 8 nke oriri PQQ gasịrị, ngbanwe nghọta nke otu ndị na-eto eto, ọsọ nhazi na akara ọsọ nke igbu egbu mụbara.

02 PQQ nwere ike ọ bụghị naanị ịkwalite ọrụ ụbụrụ nke ndị agadi, kamakwa imezi nzaghachi ụbụrụ nke ndị na-eto eto!

Na Machị 2023, akwụkwọ akụkọ a ma ama n'ụwa niile bụ Food & Function bipụtara akwụkwọ nyocha akpọrọ "Pyrroloquinoline quinone disodium nnu na-eme ka ọrụ ụbụrụ na-arụ ọrụ ma ndị okenye na ndị okenye". Ọmụmụ ihe a nyochara mmetụta nke PQQ na ọrụ ọgụgụ isi nke ndị okenye dị afọ 20-65, na-amụba ọnụ ọgụgụ ọmụmụ nke PQQ site na ndị agadi na ndị na-eto eto. Ọmụmụ ihe ahụ gosipụtara na PQQ nwere ike imeziwanye ọrụ ọgụgụ isi nke ndị nọ n'afọ ndụ niile.

Nnyocha achọpụtala na PQQ, dị ka nri na-arụ ọrụ, nwere ike imeziwanye ọrụ ụbụrụ n'oge ọ bụla, a na-atụkwa anya ka ọ gbasaa iji PQQ dị ka nri na-arụ ọrụ site na ndị agadi na ndị nọ n'afọ ndụ niile.

03 PQQ na-arụ ọrụ dị ka onye na-arụ ọrụ nke "ụlọ ọrụ ike cell" iji weghachi ahụike ha

Na Mee 2023, Cell Death Dis bipụtara akwụkwọ nyocha akpọrọ oke ibu na-emebi mitophagy dabere na cardiolipin na ike nnyefe intercellular mitochondrial nke mkpụrụ ndụ mesenchymal. Ọmụmụ ihe a chọpụtara PQQ site n'inyocha ma ikike inye onyinye intercellular mitochondrial nke ndị buru oke ibu (ndị nwere nsogbu metabolic) na mmetụta ọgwụgwọ nke mkpụrụ ndụ mesenchymal stem cell (MSCs) adịghị emebi, yana ma ọgwụgwọ ezubere iche mitochondrial nwere ike ịgbanwe ha. Mgbanwe na-eweghachi ahụike mitochondrial iji belata mitophagy na-adịghị mma.
Ọmụmụ ihe a na-enye nghọta mbụ nke mkpụrụ ndụ ihe omimi nke mitophagy na-adịghị mma na mkpụrụ ndụ mesenchymal mesenchymal nke oke ibu ma gosipụta na enwere ike iweghachi ahụike mitochondrial site na ụkpụrụ PQQ iji belata mitophagy na-adịghị mma.

04 PQQ nwere ike melite ọrụ metabolic mmadụ

Na Mee 2023, akụkọ nyocha akpọrọ "Pyrroloquinoline-quinone iji belata mkpokọta abụba na ọganihu oke ibu" ka ebipụtara n'akwụkwọ akụkọ Front Mol Biosci, nke chịkọtara ọmụmụ anụmanụ 5 na ọmụmụ mkpụrụ ndụ abụọ.
Nsonaazụ gosiri na PQQ nwere ike ibelata abụba anụ ahụ, ọkachasị mkpokọta visceral na imeju, si otú a na-egbochi oke ibu nri. Site na nyocha ụkpụrụ, PQQ na-egbochikarị lipogenesis ma na-ebelata mkpokọta abụba site na ịkwalite ọrụ mitochondrial na ịkwalite metabolism lipid.

05 PQQ nwere ike igbochi osteoporosis nke ịka nká sitere n'okike

Na Septemba 2023, Aging Cell bipụtara akwụkwọ nyocha akpọrọ "Pyrroloquinoline quinone na-ebelata osteoporosis sitere n'okike site na akwụkwọ akụkọ MCM3-Keap1-Nrf2 axis-mediated stress nzaghachi na Fbn1 upregulation" online. Ọmụmụ ahụ, site na nnwale na ụmụ oke, chọpụtara na mgbakwunye PQQ nri nwere ike igbochi osteoporosis nke ịka nká sitere n'okike. Usoro dị n'okpuru nke ikike antioxidant siri ike nke PQQ na-enye ndabere nnwale maka iji PQQ dị ka mgbakwunye nri maka mgbochi osteoporosis metụtara afọ.
Ọmụmụ ihe a na-ekpughe ọrụ dị irè na usoro ọhụrụ nke PQQ n'igbochi na ịgwọ ọrịa osteoporosis nke agadi, ma gosipụta na PQQ nwere ike iji mee ihe dị ka ihe mgbakwunye nri dị mma ma dị irè iji gbochie ma na-agwọ ọrịa osteoporosis. N'otu oge ahụ, e kpughere na PQQ na-arụ ọrụ MCM3-Keap1-Nrf2 mgbaàmà na osteoblasts, transcriptionally kwalite okwu nke mkpụrụ ndụ ihe nketa antioxidant na Fbn1 genes, na-egbochi nrụgide oxidative na osteoclast ọkpụkpụ resorption, ma na-akwalite ọkpụkpụ ọkpụkpụ osteoblast, si otú ahụ na-egbochi ịka nká. ọrụ na omume nke osteoporosis mmekọahụ.

06 Mgbakwunye PQQ nwere ike ichebe sel ganglion retina ma melite ahụike anya!

Na Septemba 2023, akwụkwọ akụkọ Acta Neuropathol Commun bipụtara ọmụmụ sitere n'aka ndị ọkachamara n'ihe gbasara ophthalmology na ndị ọkà mmụta sitere na Anya Hospital of Karolinska Institutet na Stockholm, Sweden, ụlọ akwụkwọ ahụike Europe ama ama, yana Royal Victoria Eye and Ear Hospital na Australia, yana ngalaba nke bayoloji nke Mahadum Pisa dị na Italy. Akpọrọ ya "Pyrroloquinoline quinone na-akwalite njikọ ATP na vitro na na vivo ma na-enye nchebe retina ganglion cell neuroprotection." Nnyocha egosila na PQQ nwere mmetụta nchebe na sel ganglion retinal (RGC) ma nwee nnukwu ikike dị ka onye na-ahụ maka neuroprotective ọhụrụ n'iguzogide retina ganglion cell apoptosis.
Nchoputa a na-akwado ọrụ PQQ nwere ike dị ka onye na-ahụ maka ihe na-ahụ maka ọhụụ nke nwere ike imeziwanye ike nke mkpụrụ ndụ ganglion retina ma na-ebelata ihe ize ndụ nke mmetụta ndị nwere ike ime. N'otu oge ahụ, ndị nchọpụta kwenyere na ịgbakwunye PQQ bụ nhọrọ dị irè maka ịnọgide na-enwe ahụike anya.

07 Mgbakwunye PQQ nwere ike ịhazi flora eriri afọ, melite ọrụ thyroid, ma belata mmebi nke thyroid.

Na Disemba 2023, otu ndị nyocha sitere na Hospitallọ Ọgwụ Ndị Isi nke Shanghai nke Tongji University School of Medicine bipụtara akụkọ akpọrọ "Ọrụ Pyrroloquinoline Quinone nwere ike ịhazi thyroid Function na Gut Microbiota Composition of Graves' Disease in ụmụ oke" na akwụkwọ akụkọ Pol J Microbiol N'ime edemede a, ndị nchọpụta nwere ike iji ihe atụ na-emezigharị ihe nlereanya. flora, belata mmebi nke eriri afọ, ma melite ọrụ thyroid.
Ọmụmụ ihe ahụ chọpụtara mmetụta nke mgbakwunye PQQ na ụmụ oke GD na osisi eriri afọ ha:

01 Mgbe mgbakwunye PQQ gasịrị, a na-ebelata serum TSHR na T4 nke ụmụ oke GD, na oke nke thyroid gland belatara nke ukwuu.

02 PQQ na-ebelata mbufụt na nrụgide oxidative, ma na-ebelata obere mmebi epithelial intestinal.

03 PQQ nwere mmetụta dị ịrịba ama na iweghachi ihe dị iche iche na nhazi nke microbiota.

04 Tụnyere otu GD, ọgwụgwọ PQQ nwere ike ibelata ụbara Lactobacilli na ụmụ oke (nke a bụ ọgwụgwọ ebumnuche maka usoro GD).

Na nchịkọta, mgbakwunye PQQ nwere ike ịhazi ọrụ thyroid, belata mmebi nke thyroid, ma belata mbufụt na nrụgide oxidative, si otú ahụ na-ebelata obere mmebi epithelial intestinal. Na PQQ nwekwara ike weghachi ihe dị iche iche nke osisi eriri afọ.

Na mgbakwunye na ọmụmụ ihe ndị a dị n'elu na-egosi ọrụ dị mkpa na ikike na-enweghị njedebe nke PQQ dị ka ihe mgbakwunye nri iji meziwanye ahụike mmadụ, ọmụmụ ihe gara aga anọgidewokwa na-akwado ọrụ dị ike nke PQQ.

08 PQQ nwere ike melite ọbara mgbali elu akpa ume

N'October 2022, akwụkwọ nyocha akpọrọ "Pyrroloquinoline quinone (PQQ) na-eme ka ọbara mgbali elu na-eme ka ọ dịkwuo mma site na ịhazi ọrụ mitochondrial na metabolic" n'akwụkwọ akụkọ Pulmonary Pharmacology & Therapeutics, na-achọ ịchọpụta ọrụ PQQ na-eme ka ọbara mgbali elu dị elu.
Nsonaazụ na-egosi na PQQ nwere ike ibelata mitochondrial abnormalities na metabolic abnormalities na pulmonary artery smooth muscle cell na-egbu oge ọganihu nke pulmonary hypertension na oke; ya mere, enwere ike iji PQQ mee ihe dị ka onye nwere ike ịgwọ ọrịa iji meziwanye ọbara mgbali elu nke akpa ume.

09 PQQ nwere ike igbu oge ịka nká ma gbasaa ndụ!

Na Jenụwarị 2020, akwụkwọ nyocha akpọrọ Pyrroloquinoline quinone na-egbu oge mbufụt nke TNF-α na-ebute site na p16/p21 na ụzọ akara Jagged1 e bipụtara na Clin Exp Pharmacol Physiol gosipụtara ozugbo mmetụta mgbochi ịka nká nke PQQ na sel mmadụ. , nsonaazụ na-egosi na PQQ na-egbu oge ịka nká mmadụ ma nwee ike ịgbatị ndụ ndụ.

Ndị nchọpụta chọpụtara na PQQ nwere ike igbu oge ịka nká mmadụ, wee chọpụta nkwubi okwu a site na nkwupụta nke ọtụtụ biomarkers dị ka p21, p16, na Jagged1. A na-atụ aro na PQQ nwere ike imeziwanye ahụike nke ọha mmadụ ma gbasaa ogologo ndụ.

10 PQQ nwere ike igbochi ịka nká ovarian ma nọgide na-enwe ọmụmụ

Na Machị 2022, akwụkwọ nyocha akpọrọ "Mgbakwunye nri nri PQQ na-egbochi Alkylating Agent-Induced Ovarian Dysfunction na ụmụ oke" n'akwụkwọ akụkọ Front Endocrinol, na-achọ ịmụ ma mgbakwunye nri PQQ na-echebe megide arụrụ arụ ọrụ ovarian na-ebute. mmetụta.
Nsonaazụ gosiri na mgbakwunye PQQ mụbara ịdị arọ na nha nke ovaries, weghachi obere okirikiri estrous mebiri emebi, ma gbochie mfu nke follicles na ụmụ oke ejiri ọgwụ alkylating mesoo. Ọzọkwa, PQQ supplementation budata ụbara ọnụ ọgụgụ afọ ime yana nha nha nha kwa nnyefe n'ime ụmụ oke a na-agwọ ndị nnọchite anya alkylating. Nsonaazụ ndị a na-egosipụta ikike ntinye aka nke mgbakwunye PQQ na arụrụ ọrụ ovary na-ebute alkylating.

Mmechi
N'ezie, dị ka ihe mgbakwunye nri ọhụrụ, PQQ amarala maka mmetụta dị mma na nri na ahụike. N'ihi ọrụ ya dị ike, nchekwa dị elu na nkwụsi ike dị mma, ọ nwere atụmanya mmepe sara mbara n'ọhịa nke nri na-arụ ọrụ.
N'ime afọ ndị na-adịbeghị anya, site n'ịmụbawanye ihe ọmụma, PQQ enwetala asambodo nrụpụta ọrụ kachasị mma ma jiri ya mee ihe dị ka ihe mgbakwunye nri ma ọ bụ nri na United States, Europe na mba na mpaghara ndị ọzọ. Ka mmata nke ndị na-azụ ahịa n'ụlọ na-aga n'ihu, a kwenyere na PQQ, dị ka ihe oriri ọhụrụ, ga-emepụta ụwa ọhụrụ n'ahịa ụlọ.

Ntụaka:

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