Urolithin A nwere ike ịbụ ihe ngwọta iji mebie nkwụsị n'ịkwado ahụike?

● Bioactivity na ịdị irè nke urolixin A

1:Mmetụta mgbochi ịka nká

Mee ka ọrụ mitochondrial dịkwuo mma: urolithin A nwere ike ịkpali mitophagy, nyere aka kpochapụ mitochondria mebiri emebi, kwalite ọgbọ ọhụrụ, mitochondria na-arụ ọrụ, iji nọgide na-enwe ike metabolism nke mkpụrụ ndụ ma na-egbu oge usoro ịka nká.

2:Mmetụta neuroprotective

Belata neuroinflammation: Urolitin A nwere ike ịgafe ihe mgbochi ụbụrụ ọbara, belata amyloid beta (Aβ) na ọnya protein tau, ma mee ka mitochondrial autophagy, si otú ahụ meziwanye mgbaàmà nke ọrịa neurodegenerative dị ka ọrịa Alzheimer na ọrịa Parkinson .Mmeziwanye ebe nchekwa ọrụ: Nnyocha egosiwo na urolixin, ebe nchekwa na-arụ ọrụ na-emeziwanye mmụta mmụta.

3:Nchedo akwara

Mee ka ike na ntachi obi dịkwuo elu: Urolixin A nwere ike ime ka ahụ ike dịkwuo mma, na-eme ka ike na ntachi obi dịkwuo elu, ma nwee ike itinye aka na ọrịa ndị metụtara muscular dystrophy. Na-akwalite mgbake muscle: Site na nhazi usoro dị ka ọrụ mitochondrial n'ime mkpụrụ ndụ akwara, urolixin A na-enyere ndị agadi aka ma ọ bụ ndị nwere ihe isi ike na-agagharị agagharị n'ihi ọrịa iji mee mgbatị ahụ achọrọ ma kwalite mgbake ahụ.

4:Mmetụta mgbochi mkpali

Mgbochi nke ihe ndị na-egbuke egbuke: urolithin A nwere ike igbochi mmepụta na ntọhapụ nke ihe ndị na-egbuke egbuke dị ka IL-6 na TNF-α, ma belata nzaghachi mkpali.Nchịkwa nke ụzọ mgbaàmà mkparị: Site n'igbochi ntinye nke NF-κB, MAPK na ụzọ mgbaàmà ndị ọzọ na-egbuke egbuke, urolitin A na-ebelata nzaghachi mkpali.

5:antioxidation

Na-ekpochapụ radicals n'efu: Urolixin A nwere ikike iwepu radicals n'efu ozugbo wee belata mmebi nke nrụgide oxidative na sel.Mee ka nchebe antioxidant dịkwuo mma: Urolixin A nwere ike ịkwalite ikike nchebe nke antioxidant endogenous nke mkpụrụ ndụ site n'ịkwalite ụzọ Nrf2 antioxidant ụzọ na elu-na-achịkwa okwu nke dị iche iche antioxidant enzymes dị ka glutathione peroxidmuse dissase na superoxide.

6:Mmetụta antitumor

Mgbochi nke mmụba cell tumor: urolixin A nwere ike igbochi mmụba, mbuso agha na metastasis nke ọrịa prostate, ọrịa cancer colon na mkpụrụ ndụ tumor ndị ọzọ. Induction nke apoptosis cell tumor: Site n'ịkwalite ụzọ mgbaàmà metụtara apoptosis, urolixin A nwere ike ime ka ụbụrụ tumor apoptosis, si otú ahụ na-egbochi uto tumor.

7:Melite ọrịa metabolic

Iwu nke shuga ọbara na lipid ọbara: urolithin A nwere ike ịhazi usoro metabolic nke anụ ahụ ma rụọ ọrụ dị mma n'ịkwalite shuga ọbara na ọkwa lipid ọbara.Mgbochi oke ibu: Site n'ịkwalite abụba agba aja aja na abụba ọcha Browning, urolixin A nwere ike mee ka catabolism abụba dịkwuo ngwa ma gbochie nchịkọta abụba kpatara nri.

8:Kwalite ọrịa akụrụ

Mbelata mmerụ ahụ akụrụ: Urolixin A nwere ike ibelata mmerụ ahụ akụrụ site n'ime ka mitochondrial autophagy nke mkpụrụ ndụ akụrụ rụọ ọrụ, na-ebelata mkpokọta collagen, ibelata mmụba fibrocyte ma ọ bụ ibelata ntinye anụ ahụ fiber iji belata mmepe nke usoro fibrosis.

● Atụmanya itinye urolitin A

1:Nnyocha ọgwụ na mmepe

Urolixin A bụ ebumnuche a ma ama maka mmepe nke ịka nká, neuroprotective, mgbochi tumor ọgwụ n'ihi ọrụ dị iche iche nke ndu ya. Ka ọ dị ugbu a, ọtụtụ ụlọ ọrụ nyocha na ụlọ ọrụ amalitela ịmụ banyere mmepe ọgwụ nke urolixin A, na-atụ anya imepụta ọgwụ dị mma na nchekwa.

2:Nchọpụta ihe ịchọ mma na mmepe

Mmetụta antioxidant na mgbochi mkpali nke urolixin A na-eme ka o nwee atụmanya ngwa ngwa n'ọhịa nke ịchọ mma. Site na ịgbakwunye urolixin A, ihe ịchọ mma nwere ike ịkwalite mmetụta mgbochi ịka nká ma melite ọnọdụ akpụkpọ ahụ.

3:Nnyocha na mmepe nri

Urolixin A nwere uru ngwa ngwa n'ọhịa nri n'ihi ọrụ dị iche iche nke ndu ya. Site na ịgbakwunye nri ellagitannin bara ụba ma ọ bụ ihe mgbakwunye urolithin A, nri nwere ike ịkwalite uru ahụike yana izute ndị ahịa chọrọ nri ahụike.

Kpọtụrụ: Judy Guo

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