Ngwaahịa
Quercetin soluble mmiri maka nnyefe ihe oriri kachasị elu
Quercetin soluble mmiri: Ịkwalite bioavailability na ịsụ ụzọ ọhụụ nke ahụike
Quercetin, ogige flavonoid nke a na-achọta n'ụba n'ụdị nri dị iche iche sitere na osisi dị ka eyịm, apụl, na mkpụrụ osisi, kemgbe ogologo oge bụ isi ihe na nyocha sayensị na nkwurịta okwu ahụike, n'ihi ike ya na-eme ka antioxidant, mgbochi mkpali, na ihe omume dịgasị iche iche nke ndụ. Agbanyeghị, mmiri solubility ya na-adịghị mma na-egbochi nnabata ya na itinye ya n'ọrụ n'ime ahụ mmadụ, si otú a na-amachi mmezu zuru oke nke uru ahụike ya. N'ime afọ ndị na-adịbeghị anya, na ọganihu na-aga n'ihu na sayensị na nkà na ụzụ, quercetin na-edozi mmiri apụtala, na-emeri ihe ịma aka nke quercetin omenala ma na-egosipụta ụdị ngwa dị iche iche na uru pụrụ iche.
Na-eme mgbanwe bioavailability: imeri ihe mgbochi absorption
Omenala quercetin, n'ihi na mmiri solubility ya dị ala, na-agbasi mbọ ike ịgbari na eriri afọ mgbe nchịkwa ọnụ gasịrị, na-ebute ọnụego nnabata dị oke ala. Nnyocha na-egosi na ọnụ ọgụgụ nnabata nke eriri afọ ya dị ihe dịka 2%. N'ụzọ dị iche, quercetin na-agbaze mmiri na-eme ka teknụzụ na-egbutu ọnụ, dị ka teknụzụ nanomicelle na nkà na ụzụ nsonye cyclodextrin, iji meziwanye ike ya na mmiri. Dị ka ọmụmaatụ, Dryland New Materials Laboratory nke South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Sciences, kwadoro nanomicelles nke quercetin na-ebu nke ọma site na ụzọ njikọ kemịkal. Ihe ọhụrụ a mere ka ọ dị mma solubility mmiri quercetin, ike foto, yana ịrụ ọrụ nke ọma. N'ihi nke a, quercetin nwere ike ịgbaze nke ọma na mmiri eriri afọ, na-abawanye mpaghara kọntaktị ya na mkpụrụ ndụ mucosal intestinal ma na-abawanye arụmọrụ ya n'ime ahụ mmadụ. Ọmụmụ ihe dị mkpa na-egosi na enwere ike ịbawanye bioavailability nke quercetin na-agbaze mmiri site na ọtụtụ ugboro ma ọ bụ karịa ma e jiri ya tụnyere quercetin ọdịnala, na-eme ka ahụ nwee ike ịmịnye ma jiri ihe ndị na-arụ ọrụ nke quercetin na-emepe emepe ma meghee mmetụta ya na-akwalite ahụ ike.
Ngwa ahụike dị iche iche
1. Iwu Glucose ọbara
quercetin nwere mmiri soluble na-enye olileanya ọhụrụ maka ndị mmadụ na-eche gbasara ahụike glucose ọbara. Nnyocha nke Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences mere, ekpughere na quercetin na ngwakọta flavonoids ndị ọzọ nwere ike igbochi ọrụ α-glucosidase. α-Glucosidase na-arụ ọrụ dị oke mkpa na hydrolysis nke carbohydrates, na igbochi ọrụ ya nwere ike igbochi mgbaze na absorption nke carbohydrates nke ọma, si otú a na-enyere aka ịchịkwa ọkwa glucose ọbara postprandial. Site na ikesa ya nke ọma na nnabata ya, quercetin nwere ike soluble mmiri nwere ike isonye nke ọma na mgbochi α-glucosidase, na-enye nkwado siri ike maka mmepe nke ngwaahịa na-arụ ọrụ iji na-ahazi glucose ọbara postprandial. Nke a nwere mmetụta dị ukwuu maka nlekọta ahụike kwa ụbọchị nke ndị ọrịa shuga ma ọ bụ ndị nwere ọkwa glucose ọbara na-agbanwe.
2. Nchekwa ahụike imeju
quercetin na-agbaze mmiri na-enwukwa n'ịkwado ahụike imeju. Nnyocha nke ndị otu Prọfesọ Peng Cheng si na Mahadum Chengdu nke Medicine Chinese ọdịnala egosila na quercetin nwere ike imezi imeju abụba mmanya na-aba n'anya site n'ịgbazigharị ntụgharị nuklia nke TFEB iji kwụọ ụgwọ maka autophagy ezughị ezu. Mmụba nke quercetin na-agbaze mmiri na-enye ya ohere iru imeju ngwa ngwa na nke ọma, na-ewusi ọrụ autophagic nke mkpụrụ ndụ imeju ike, na-akwalite metabolism nke abụba n'ime imeju, na-eme ka ikpochapụ ihe ndị na-emerụ ahụ. Nke a na-enyere aka igbochi ma melite ọrịa imeju dị iche iche, dị ka imeju abụba abụba na ọrịa imeju mmanya na-egbu egbu, site n'ibelata mmebi mmanya na ihe ndị ọzọ na-akpata imeju.
3. Nkwalite ntutu isi
Ọnwụ ntutu bụ ihe na-echegbu ọtụtụ ndị mmadụ, na quercetin na-edozi mmiri na-enye ngwọta ọhụrụ maka nsogbu a. Nnyocha nke otu Prọfesọ Qu Jing sitere na Institute of Zoology, Chinese Academy of Sciences, achọpụtala na quercetin nwere ike ịkwalite ntutu isi n'ụzọ dị irè site n'ịkwalite ụzọ HIF-1 na sel endothelial nke microenvironment ntutu isi. quercetin na-agbaze mmiri nwere ike ịbanye n'ọbara n'enweghị nsogbu ma rute ebe ntutu isi, na-arụ ọrụ nhazi ya nke ọma na microenvironment ntutu isi. Ọ na-akpali ọdịiche na mmụba nke mkpụrụ ndụ sel follicle ntutu, si otú ahụ na-akwalite uto ntutu. Ma ntutu isi na-akpata bụ nchekasị, ndakpọ nke homonụ, ma ọ bụ ihe ndị ọzọ, quercetin na-edozi mmiri na-ekwe nkwa dị ka ọgwụgwọ adjuvant dị mma ma dị irè.
4. Mmelite sistemu mgbochi
Quercetin n'onwe ya nwere ụfọdụ ihe omume immunomodulatory, dị ka ịkwalite ịgbalite macrophage na nzuzo nke ihe mgbochi ndị metụtara ya. Ọbịbịa nke quercetin na-agbaze mmiri na-abawanye uru ndị a. Mmiri mmiri ya dị mma na-eme ka nkesa dị iche iche dị n'ime ahụ, na-enyere ya aka ime ihe kpọmkwem na akụkụ dị iche iche nke usoro ahụ ji alụso ọrịa ọgụ. Ọ na - eme ka ọrụ nke mkpụrụ ndụ na - alụso ọrịa ọgụ dịkwuo elu ma na - akwalite nzuzo nke ihe ndị na - alụso ọrịa ọgụ dị ka tumor necrosis factor-α na interferon-γ, na-enyere anụ ahụ aka ịgbachitere onwe ya pụọ na nje ndị dị n'èzí ma na-akwalite nchebe zuru oke. Nke a na-enye ndị mmadụ ike inwe nguzogide siri ike mgbe ha na-eche ihe egwu ahụike dị ka nje influenza na nje nje.
Profaịlụ nchekwa na atụmanya Ọdịnihu
Nkwadebe nke quercetin na-agbaze mmiri na-ejikarị na-eji ụzọ nka nka dị mma na gburugburu ebe obibi, dị ka teknụzụ nanomicelle a kpọtụrụ aha na mbụ. Ụzọ ndị a na-eme ka mmiri quercetin dịkwuo mma na-enweghị iwebata kemịkalụ na-emerụ ahụ, na-ahụ na nchekwa ngwaahịa ahụ. Ọzọkwa, n'ihi mmụba bioavailability ya, a chọrọ obere dose nke quercetin iji nweta otu uru ahụike ahụ, na-ebelata ohere nke mmeghachi omume ọjọọ.
Site na nyocha nke nyocha na-aga n'ihu na teknụzụ teknụzụ na-aga n'ihu, quercetin na-agbaze mmiri dị njikere igosipụta ikike ngwa ngwa ka ukwuu na nri arụ ọrụ, ihe mgbakwunye nri, ihe ịchọ mma, na ụlọ ọrụ ọgwụ. N'ebe nri na-arụ ọrụ, enwere ike itinye ya n'ime ihe ọṅụṅụ na nri dị iche iche, na-enye ndị na-azụ ahịa nchebe ahụike dị mma. N'ime ụlọ ọrụ ịchọ mma, na-eme ka ntutu ya na-eme ka ntutu ya dịkwuo mma na ihe antioxidant, enwere ike ịmepụta ngwaahịa ndị nwere ọrụ dịka ntutu isi na mgbochi akpụkpọ ahụ. N'ime ụlọ ọgwụ, enwere nkwa dị ukwuu maka ịga n'ihu na-enyocha ngwa ya n'ịgwọ ọrịa na-adịghị ala ala na inye aka na ọgwụgwọ ọgwụ, na-emepe ọhụụ ọhụrụ maka nyocha ahụike na ahụike n'ọdịnihu.
Ntụaka
1.South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Sciences. (nd). Ọganihu ọhụrụ dị na Nano Sustained-Wepu Drug Carrier Materials. Ewepụtara na http://m.toutiao.com/group/7164215338974839308/?upstream_biz=doubao
2.Peng, C., et al. (nd). Quercetin na-ebelata ethanol - kpalitere steatosis imeju na sel L02 site na ịgbalite ntụgharị TFEB iji kwụọ ụgwọ maka autophagy ezughị oke. Nchọpụta PHYTOTHERAPY (Ụdị nke abụọ na ụlọ akwụkwọ sayensị China). Ewetara na ọdụ data agụmakwụkwọ
3.Qu, J., et al. (nd). Profaịlụ otu mkpụrụ ndụ otu-na-ekpughe ọrụ dị ike nke Quercetin n'ịkwalite mmeghari ntutu. Protein & cell. Ewetara na https://m.thepaper.cn/newsDetail_forward_21318679
4.Jin, Z., et al. (2024). Co - encapsulation nke quercetin na resveratrol: atụnyere n'ụdị dị iche iche nke zein - carboxymethyl cellulose nanoparticles. Akwụkwọ akụkọ International nke Biological Macromolecules, 263, Nkeji edemede 127439. https://doi.org/10.1016/j.ijbiomac.2024.127439
5.Zhengzhou Mkpụrụ Research Institute, Chinese Academy of Agricultural Sciences. (2024). Flavonoids dị na mkpụrụ osisi na-achịkwa glucose ọbara mgbe nri gasịrị. Ewepụtara na http://www.xinhuanet.com/science/20241105/c730eb7ee20a4e0ab8d2ec96570044ca/c.html
